A: The main difference between Δ8-THC and Δ9-THC is how it interacts with the CB1 and CB2 receptors in the body’s endocannabinoid system. Δ8-THC binds to the CB1 and CB2 receptors which are located in the central nervous system, similar to THC. The difference between the two is where the the bonds are contained on a molecular chain. Δ8-THC contains its bond on the 8th carbon chain while Δ9-THC's bond is on the 9th carbon chain. This small difference actually causes notable contrasts in how the endocannabinoid’s receptors bind and respond to the molecule. This minor difference reduces the psychotropic effects of Δ8-THC when compared to Δ9-THC.